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Woman getting pregnant by bone marrow

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Credit: Getty Images. The study shows that when an egg is fertilized, stem cells leave the bone marrow and travel via the bloodstream to the uterus, where they help transform the uterine lining for implantation. If the lining fails to go through this essential transformation, the embryo cannot implant, and the body terminates the pregnancy. But knowing that bone marrow has a significant role is a paradigm shift. In this study, the researchers were able to prove the physiological relevance of stem cells to pregnancy.

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Pregnancy in Bone Marrow Failure Disease

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It may be hard to get and stay pregnant for some would-be mums, but there is hope. Scientists have discovered the vital role bone marrow plays in pregnancy, which can lead to new therapies in the future. In 10 seconds? Stem cells play a key role in successful pregnancies. Read the science. What exactly was discovered? Stem cells arriving from the bone marrow to the uterus transform its lining and help the implantation of the embryo by becoming decidual cells essential for getting and staying pregnant.

If this transformation does not occur, the pregnancy will terminate. Read the paper. What mechanism is at play here?

It turns out they also help transform the endometrium, the inner lining of the uterus. A damaged endometrium can result in repeated lost pregnancies or infertility and the findings raise the hope of science being able to fix this condition.

More on factors affecting embryonic implantation. So, how did they discover this? Earlier attempts also destroyed the mice's eggs, but the researchers have managed to refine their technique to keep them intact this time.

The next step was to make two groups of mice pregnant, one before and one after a healthy bone marrow transplant to test if bone marrow played a role in pregnancy. Find out more. Which they proved, right? Anything else they discovered?

For this study, they investigated the role of the protein Hoxa11, present in both the bone marrow and the uterus. When Hoxa11 is partially absent, lab mice cannot maintain their pregnancies and when it is completely lacking, pregnancy doesn't even start.

But when partially or completely Hoxadeprived mice receive bone marrow transplants from healthy peers, both groups gain the ability to become pregnant. Read more. What can we expect in the future? The study was done in mice and Hoxa11 is worthy of further investigation before human trials can begin.

The findings - that a bone marrow transplant from a healthy donor could improve fertility - are great news. Up to now, there was no effective treatment for the majority of women with recurrent implantation failure and loss of pregnancies due to endometrial defects, therefore the discovery offers hope for new therapies and the possibility of having babies in the future.

Four years later a Japanese team repeated the feat and managed to generate sperm that produced healthy and fertile mice. Researchers described the studies as the first steps to produce sperm for infertile men or potentially allow same-sex female couples to produce artificial sperm and have their own biological daughters. Endre Szvetnik is Senior Editor at Sparrho. Endre works with Sparrho Heroes to curate, translate and disseminate scientific research to the wider public.

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You consent to our cookies if you continue to use this website. Read more about how we use cookies. Log in Sign up. Log in. Sign up. How bone marrow boosts chances of a healthy pregnancy. Read the science What exactly was discovered? Read the paper What mechanism is at play here? More on factors affecting embryonic implantation So, how did they discover this? Find out more Which they proved, right? Read more What can we expect in the future? Curated by Endre Szvetnik. Read next Is stretching a way to beat back tumours?

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Pregnancy following Bone Marrow Transplant

But recently a team of scientists announced they had made artificial sperm from human bone marrow , and media reports abounded with the dire news that my goodfellas and by extension, me had been rendered unnecessary. There are at least half a dozen reasons why such speculation is silly, some scientific and some practical. For example, as long as sex feels good and remains no more expensive than dinner and a bottle of wine, most people will use natural-grown sperm.

Stem cells have generated such an enormous amount of interest, in part, because of their applications related to areas such as fertility and genetics. In that same light, their interest for solving reproductive challenges has also generated a great deal of controversy.

Bone marrow-derived cells play a role in changes to the mouse uterus before and during pregnancy, enabling implantation of the embryo and reducing pregnancy loss, according to research published September 12 in the open-access journal PLOS Biology. Although the study was done in mice, it raises the possibility that dysfunction of bone marrow-derived progenitor cells may contribute to implantation failure and pregnancy loss in women. Bone marrow progenitors can become either blood or tissue cells. Within the uterus they differentiate into endometrial tissue cells in the lining of the womb, but until now it was not known if they have a function in pregnancy. Reshef Tal and colleagues from Yale School of Medicine developed a bone marrow transplantation protocol that preserved ovary and reproductive function, allowing them for the first time to track these cells in pregnancy, showing that during pregnancy cells from the bone marrow were preferentially recruited to the uterus and were concentrated near the site of implantation, on the maternal side of the placenta.

Bone marrow may be the missing piece of the fertility puzzle

Researchers found that when an egg is fertilised, stem cells leave the bone marrow and travel via the bloodstream to the uterus, where they help transform the uterine lining for implantation. If the lining fails to go through this essential transformation, the embryo cannot implant, and the body terminates the pregnancy. Study first author Dr. Using mice, researchers found that a bone marrow transplant from a healthy donor could improve fertility. This study was made possible by a methods breakthrough that Dr Tal and Prof Taylor made a few years ago. Though more research is needed prior to clinical trials, the research team see hope for the patients they treat for infertility on the clinical side of their practice. Your email address will not be published.

Woman’s bone marrow may determine her fertility

Catch up on stories from the past week and beyond at the Slashdot story archive. I guess after being told to "Go Fuck Yourself" for so many years, these scientists finally found a way to do it. There will be some interesting debates raging about this one for a long time. I'm of the opinion that on the whole, we are better off with the process of gene mixing than practicing self-eugenics.

Bone marrow failure diseases frequently occur in women who are young and of child bearing age.

It may be hard to get and stay pregnant for some would-be mums, but there is hope. Scientists have discovered the vital role bone marrow plays in pregnancy, which can lead to new therapies in the future. In 10 seconds?

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The study shows that when an egg is fertilized, stem cells leave the bone marrow and travel via the bloodstream to the uterus, where they help transform the uterine lining for implantation. If the lining fails to go through this essential transformation, the embryo cannot implant, and the body terminates the pregnancy. But knowing that bone marrow has a significant role is a paradigm shift. In this study, the researchers were able to prove the physiological relevance of stem cells to pregnancy. Reshef Tal , first author of the study and assistant professor of obstetrics, gynecology and reproductive sciences at Yale. In two mouse models with the Hoxa11 gene defect, which presents in mice as a defective endometrium, the researchers found that a bone marrow transplant from a healthy donor could improve fertility by promoting sufficient decidualization of the endometrium.

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Notice: You are viewing an unstyled version of this page. Are you using a very old browser? If so, please consider upgrading. Menu In this section. With improved survival rates and assisted reproductive techniques, such as IVF, an increasing number of women are conceiving who had cancer treatment as a child or young adult [1]. Childhood and young adult cancer survivors are at increased risk of adverse pregnancy outcomes, including preterm birth particularly if they have had pelvic or abdominal radiation.

Jan 20, - What is the incidence of women conceiving after bone marrow transplant? What is the rate of adverse pregnancy outcomes in women who.

By Roxanne Khamsi. In a first step towards creating artificial sperm cells, researchers have turned human bone marrow tissue into primitive sperm cells. If these precursor cells can be coaxed into becoming fully functioning sperm cells, the technique could allow infertile men to father their own children, and even allow women to produce their own sperm. But experts caution that provoking the sperm precursors to fully mature presents a serious challenge.

Bone marrow stem cells may be vital for pregnancy

Since the late s, scientists have explored how to produce sperm where all of the chromosomes come from a female donor. Creating female sperm was first raised as a possibility in a patent filed in [3] by injecting a woman's cells into a man's testicles, though the patent focused mostly on injecting altered male cells into a man's testes to correct genetic diseases. In , Japanese scientists partially confirmed such techniques by creating chicken female sperm in a similar manner.

Bone stem cells turned into primitive sperm cells

The breakthrough paves the way for lesbian couples to have children that are biologically their own. Researchers at Newcastle upon Tyne University say their technique will help lead to new treatments for infertility. But critics warn that it sidelines men and raises the prospect of babies being born through entirely artificial means.

Log in Advanced Search. A study in mice suggests that bone marrow-derived stem cells may play a role in establishing pregnancy.

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